Fel D1 Antibody from MyBioSource.com

A number of house pet bourn allergens have been studied for allergic reactions in general population. Some of these allergens namely Fel D1 (cat), Can f1(dog), Der p1 and Der f1 (mite) are carried by the pet owners to the public places like classroom, restaurants, public library etc., and the clothes and upholstered furniture act as reservoirs for these allergens. Domestic cat (Felis domestica) is an important source of indoor allergen Fel D1, that affected a large population. Fel D1 is also established to cause cat induce asthma in sensitive patients. The levels of Fel d1 and Can f1 were high in homes of former pet-owners compared to the homes without pets. Children with mild allergy to animal dander, may have profound increase in bronchial sensitivity (increased sputum esinophil peroxidase (EPO) and myeloperoxidase (MPO) activity as a result of constant exposure of animal allergens (Fel D1 and Can f1) at public places. Allergic reactions to Fel D1 is effectively reduced by conventional immunotherapy in many patients, but this type of immunotherapy has severe reactions, including anaphylaxix and requires several years of injections for successful desensitization. Several strategies have been employed to address these issues including use of cat allergen peptides (2), chimerric constructs of Fel D1 and Fc portion of human IgEs (4). The synthetic cat allergen peptides lack the tertiary structure of native Fel D1 and posses reduced capacity to bind Fel D1-specific IgE. These peptides when given to patients sensitive to cat allergens showed improvement in pulmonary function and tolerance to cats (2). The exposure of chimeric human -cat fusion protein composed of truncated human IgGFcgamma1 and the Fel D1. the chimeric protein induce dose dependent inhibition of Fel D1-driven IgE mediated histamine release form cat allergic donors (3). The allergen is a 38 kDa dimer composed of two 19 kDa subunits. Each 19 kDa subunit comprises two disulfide linked polypeptide chains, a light alpha-chain and a heavy beta-chain containing an N-linked oligosaccharide. The alpha light chain and the heavy beta chain are linked in an anti-parallel configuration. The Fel D1glycosylation atr Asn 33 is of heterogeneous triantennary structure caused by terminal sialic acid and fucose residues attached to beta-galactose residues. MyBioSource has made anti-Fel D1-selective antibodies against 3 epitopes covering the majority of the protein. The affinity purified mono-specific polyclonal antibodies to FEl D1 strongly labels a 15-18 kDa protein in cat saliva samples examined. MyBioSource will also conjugate antibodies with fluorescent probes upon request at extra charge. MyBioSource employs cyclic peptide methodology for generating antibodies, which results in higher titer and specificity (3). MyBioSource, will also provide Western blot positive controls most of its antibodies in ready-to-use buffer for easy identification of respective proteins. Limited quantities of antigens/blocking peptides are also available. Please enquire for their availability before ordering